2018 Research Articles
2018 VISN 20 MIRECC Staff Research Articles and PresentationsThe findings of NW MIRECC research are disseminated through MIRECC Presents, lectures and presentations, and publications. Below is a list of publications and presentations by VISN 20 NW MIRECC researchers and fellowship program faculty that were published in 2018.
Adams, M. H., Dobscha, S. K., Smith, N. X., Yarborough, B. J., Deyo, R. A., & Morasco, B. (2018). Prevalence and
ABSTRACT: The pain experience may vary greatly among individuals reporting equally high levels of pain. We sought to examine the demographic and clinical characteristics associated with pain interference in patients with high pain intensity. Among patients with chronic musculoskeletal pain who were prescribed long-term opioid therapy... Read full research article: Prevalence and correlates of low pain interference among patients with high pain intensity who are prescribed long-term opioid therapy
Balba, N. M., Elliott, J. E., Weymann, K. B., Opel, R. A., Duke, J. W., Oken, B. S., ... & Lim, M. M. (2018). Increased
ABSTRACT: Veterans are at an increased risk for traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD), both of which are associated with sleep disturbances and increased pain. Furthermore, sleep disturbances and pain are reciprocally related such that each can exacerbate the other. Although both TBI and PTSD are independently linked to sleep disturbances and pain, it remains unclear whether Veterans with comorbid TBI+PTSD show worse sleep disturbances and pain compared to those with only TBI or PTSD. We hypothesized that sleep and pain would be worse in Veterans with comorbid TBI+PTSD compared to Veterans with only TBI or PTSD. Read full research article: Increased sleep disturbances and pain in veterans with comorbid Traumatic Brain Injury and Posttraumatic Stress Disorder
Boffa, J., Norr, A. M., Tock, J., Amir, N., & Schmidt, N. (2018). Development of the Interpretation Bias Index for PTSD.
ABSTRACT: Cognitive models of posttraumatic stress disorder (PTSD) implicate interpretation biases as a maintaining factor of symptoms. Existing measures index symptoms and negative beliefs in PTSD patients, but not threatening interpretation of socially-ambiguous information, which would further inform cognitive models of PTSD. Here we describe the development of a measure of interpretation bias specific to individuals with PTSD.
Browne, K., Dolan, M., Simpson, T. L., Fortney, J., & Lehavot, K. (2018). Regular past year cannabis use in women veterans
ABSTRACT: This study sought to describe the prevalence of regular past year cannabis use (i.e., at least monthly use) in women veterans, to characterize women veterans reporting this level of use, and to examine the independent contributions of sexual trauma across the lifespan on regular past year cannabis use.
Carlson, K. F., Gilbert, T. A., Morasco, B. J., Wright, D., Otterloo, J. V., Herrndorf, A., & Cook, L. J. (2018). Linkage
ABSTRACT: Examines the prevalence of concurrent Veterans Health Administration (VA) and non‐VA prescriptions for opioids and sedative‐hypnotic medications among post‐9/11 veterans in Oregon.... Read full research article: Linkage of VA and state prescription drug monitoring program data to examine concurrent opioid and sedative-hypnotic prescriptions among veterans
Dash, G. F., Wilson, A. C., Morasco, B. J., & Feldstein Ewing, S. W. (2018). A model of the intersection of pain and
ABSTRACT: Despite being a significant public health concern, the role of opioid prescriptions in potentiating risk of opioid misuse in the context of pediatric pain has been underinvestigated. To address this gap, the present review identifies theory-based hypotheses about these associations, reviews the extant literature on opioid prescriptions that supports these hypotheses, and provides routes for future empirical studies. Read full research article: A model of the intersection of pain and opioid misuse in children and adolescents
Deming, Y., Dumitrescu, L., Barnes, L., Thambisetty, M., Kunkle, B., Gifford, K., … & Hohman, T. (2018). Sex-specific
ABSTRACT: Cerebrospinal fluid (CSF) levels of amyloid-β 42 (Aβ42) and tau have been evaluated as endophenotypes in Alzheimer's disease (AD) genetic studies. Although there are sex differences in AD risk, sex differences have not been evaluated in genetic studies of AD endophenotypes. We performed sex-stratified and sex interaction genetic analyses of CSF biomarkers to identify sex-specific associations.
Hendrickson, R. C., Nishanth, J., & Michael, S. (2018). Diagnostic prevalence of common psychiatric comorbidities of
ABSTRACT: The diagnostic prevalence of mood and anxiety disorders in Indian individuals with alcohol use disorders (AUDs) has important implications for clinical decision making and for cross-cultural psychiatry research. Here, we present a systematic review of comorbid mood and anxiety disorders in Indian patients with AUDs.
Hendrickson, R. C., Raskind, M. A., Millard, S., Sikkema, C., Terry, G., Pagulayan, K. F., … & Peskind, E. R. (2018).
ABSTRACT: Increases in the quantity or impact of noradrenergic signaling have been implicated in the pathophysiology of posttraumatic stress disorder (PTSD). This increased signaling may result from increased norepinephrine (NE) release, from altered brain responses to NE, or from a combination of both factors. Here, we tested the hypothesis that Veterans reporting a history of trauma exposure would show an increased association between brain NE and mental health symptoms commonly observed after trauma.
Hendrickson, R. C., Schindler, A., & Pagulayan, K. F. (2018). Untangling PTSD and TBI: Challenges and strategies in
ABSTRACT: Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) can result from similar injuries and can result in similar symptoms, such as problems with sleep, concentration, memory, and mood. Although PTSD and persistent sequelae due to a TBI (PST) have generally been viewed as pragmatically confounded but conceptually separable entities, we examine emerging evidence emphasizing the breadth of overlap in both clinical presentation and underlying pathophysiology between PST and PTSD.
Hulen, E., Saha, S., Morasco, B., Zeigler, C., Mackey, K., & Edwards, S. (2018). Sources of distress in primary
ABSTRACT: The objective of the study was to explore provider perspectives surrounding opioid prescribing in the context of the early implementation of a multidisciplinary group, called the Controlled Substance Review Group, that provided structured opioid case discussion and consultation to primary care providers.
Kow, R., Sikkema, C., Wheeler, J., Wilkinson, C., & Kraemer, B. C. (2018). Dopa decarboxylase modulates tau toxicity.
ABSTRACT: The microtubule-associated protein tau accumulates into toxic aggregates in multiple neurodegenerative diseases. We found previously that loss of D2-family dopamine receptors ameliorated tauopathy in multiple models including a Caenorhabditis elegans model of tauopathy.
Krystal, J. H., Davis, L. L., Neylan, T. C., Raskind, M. A., Schnurr, P. P., Stein, M. B., … & Huang, G. D. (2018).
Kumthekar, A. A., Shull, S., Lovejoy, T., Morasco, B., Chang, M., & Barton, J. (2018). Eradication of Hepatitis C
ABSTRACT: Hepatitis C virus is associated with chronic wide spread pain, fatigue, myalgia, arthritis, sicca symptoms and vasculitis. Data regarding prior interferon-based treatment of Hepatitis C virus on pain is conflicting and the impact of direct acting antivirals on extrahepatic manifestations is unknown. The study objective is to assess the impact of direct acting antivirals treatment on pain and opioid use among patients treated at a single VA medical center. Read full research article: Eradication of Hepatitis C among US veterans: Examination of changes in pain severity and prescription opioid use following treatment
Lehavot, K., Goldberg, S., Chen, J., Katon, J., Glass, J., Fortney, J., … & Schnurr, P. P. (2018). Do trauma type,
ABSTRACT: To examine factors that account for women veterans’ higher prevalence of past-year DSM-5 posttraumatic stress disorder (PTSD) compared to women civilians and men veterans. Number of trauma types, type of trauma, and social factors may together help explain women veterans’ higher PTSD prevalence compared to women civilians, but do not fully account for differences between men and women veterans. Results highlight a need to explore additional explanatory factors and evaluate associations with longitudinal data.
Lehavot, K., Katon, J., Chen, J., Fortney, J., & Simpson, T. L. (2018). Post-traumatic Stress Disorder by gender and
ABSTRACT: Population-based data on the prevalence, correlates, and treatment utilization of post-traumatic stress disorder by gender and veteran status are limited. With changes in post-traumatic stress disorder diagnostic criteria in 2013, current information from a uniform data source is needed. Conclusions: Post-traumatic stress disorder is a common mental health disorder that varies by gender and veteran status. Women veterans' high rates of post-traumatic stress disorder highlight a critical target for prevention and intervention, whereas understanding treatment barriers for men veterans and civilians is necessary.
Logsdon, A., Meabon, J., Cline, M., Bullock, K., Raskind, M. A., … & Cook, D. G. (2018). Blast exposure elicits blood-brain
ABSTRACT: Mild blast-induced traumatic brain injury (TBI) is associated with blood-brain barrier (BBB) disruption. However, the mechanisms whereby blast disrupts BBB integrity are not well understood. To address this issue BBB permeability to peripherally injected 14C-sucrose and 99mTc-albumin was quantified in ten brain regions at time points ranging from 0.25 to 72 hours.
Lovejoy, T. I., Morasco, B. J., Demidenko, M. I., Meath, T. H. A., & Dobscha, S. K. (2018). Clinician referrals for
ABSTRACT: Little is known about pain care offered to patients discontinued from long-term opioid therapy (LTOT) by their prescriber due to aberrant behaviors versus other reasons. This study aimed to compare rates of non-opioid analgesic pharmacotherapy initiation and clinician referrals for non-pharmacologic pain treatment, complementary and integrative pain therapies, and specialty mental health and substance use disorder treatment between patients discontinued from opioid therapy due to aberrant behaviors versus other reasons. Read full research article: Clinician referrals for non-opioid pain care following discontinuation of long-term opioid therapy differ based on reasons for discontinuation
Lovejoy, T., Morasco, B., Meath, T., Wyse, J., & Dobscha, S. (2018). (182) - Pain care utilization following episodes of
Lozier, C. C., Nugent, S. M., Smith, N. X., Yarborough, B. J., Dobscha, S. K., Deyo, R. A., & Morasco, B. J. (2018).
ABSTRACT: Non-pharmacologic treatments (NPTs) are recommended for chronic pain. Information is limited on patient use or perceptions of non-pharmacologic treatments. We examined the frequency and correlates of use and self-rated helpfulness of NPTs for chronic pain among patients who are prescribed long-term opioid therapy. Read full research article: Correlates of use and perceived effectiveness of non-pharmacologic strategies for chronic pain among patients prescribed long-term opioid therapy
McClure, E. A., Baker, N., Sonne, S. C., Ghitza, U. E., Tomko, R. L., Montgomery, L., Babalonis, S., Terry, G., & Gray, K. M. (2018).
ABSTRACT: It is common for cannabis users to also use tobacco. While data suggest that tobacco users have more difficulty achieving cannabis cessation, secondary analyses of clinical trial data sets may provide insight into the moderating variables contributing to this relationship, as well as changes in tobacco use during cannabis treatment. Those were the aims of this secondary analysis.
McPherson, S., Smith, C. L., Dobscha, S. K., Morasco, B. J., Demidenko, M. I., Meath, T. H. A., ... Lederhos Smith, C. (2018).
ABSTRACT: Little is known about changes in pain intensity that may occur after discontinuation of long-term opioid therapy. The objective of this study was to characterize pain intensity after opioid discontinuation over 12 months. This retrospective U.S. Department of Veterans Affairs (VA) administrative data study identified 551 patients nationally who discontinued long-term opioid therapy. Read full research article: Changes in pain intensity after discontinuation of long-term opioid therapy for chronic noncancer pain
Meyerhoff, D. J., Murray, D., Durazzo, T., & Pennington, D. L. (2018). Brain GABA and glutamate concentrations following chronic
ABSTRACT: Gabapentin (GBP), a GABA analog that may also affect glutamate (Glu) production, can normalize GABA and Glu tone during early abstinence from alcohol, effectively treating withdrawal symptoms and facilitating recovery. Using in vivo magnetic resonance spectroscopy, we tested the degree to which daily GBP alters regional brain GABA and Glu levels in short-term abstinent alcohol-dependent individuals.
Morasco, B., Lovejoy, T., Hyde, S., Shull, S., & Dobscha, S. (2018). (231) - Limitations of pain numeric rating scale scores
Morasco, B. J., Lovejoy, T. I., & Ilgen, M. A. (2018). Management of chronic pain in patients with a comorbid substance use
Morasco, B. J., Shull, S. E., Adams, M. H., Dobscha, S. K., & Lovejoy, T. I. (2018). Development of an algorithm to identify
Murray, D., Durazzo, T., Schmidt, T. P., Murray, T. A., Abé, C., Guydish, J., & Meyerhoff, D. J. (2018). Regional cerebral blood
ABSTRACT: Neuroimaging of opiate-dependent individuals indicates both altered brain structure and function. Magnetic resonance-based arterial spin labeling has been used to measure noninvasively cerebral blood flow (i.e. perfusion) in alcohol, tobacco and stimulant dependence; only one arterial spin labeling paper in opiate-dependent individuals demonstrated frontal and parietal perfusion deficits. Additional research on regional brain perfusion in opiate dependence and its relationship to cognition and self-regulation (impulsivity, risk taking and decision making) may inform treatment approaches for opiate-dependent individuals.
Norr, A. M., Smolenski, D., & Reger, G. (2018). Effects of prolonged exposure and virtual reality exposure on suicidal ideation in
ABSTRACT: The current study sought to investigate the effects of exposure therapy on suicidal ideation (SI), as well as potential mechanistic pathways of SI reduction among active duty military personnel.
Nugent, S. M., Yarborough, B. J., Smith, N. X., Dobscha, S. K., Deyo, R. A., Green, C. A., & Morasco, B. J. (2018). Patterns and
ABSTRACT: Little is known about co-occurring long-term opioid therapy and medical cannabis use. We compared characteristics of patients prescribedlong-term opioid therapy who endorsed using medical cannabis for pain to patients who did not report cannabis use. Read full research article: Patterns and correlates of medical cannabis use for pain among patients prescribed long-term opioid therapy
Pagulayan, K. F., Petrie, E., Cook, D. G., Hendrickson, R. C., Rau, H., Reilly, M., … & Kleinhans, N. (2018). Effect of blast-related
ABSTRACT: Reduced working memory is frequently reported by Veterans with a history of blast-related mild traumatic brain injury (mTBI), but can be difficult to quantify on neuropsychological measures. This study aimed to improve our understanding of the impact of blast-related mTBI on the working memory system by using resting state functional magnetic resonance imaging (fMRI) to explore differences in functional connectivity between OEF/OIF/OND Veterans with and without a history of mTBI.
Pagulayan, K. F., Rau, H., Madathil, R., Werhane, M., Millard, S., Petrie, E., … & Peskind, E. R. (2018). Retrospective and
ABSTRACT: Objectives: To evaluate prospective and retrospective memory abilities in Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) Veterans with and without a self-reported history of blast-related mild traumatic brain injury (mTBI).
Painter, J. M., Brignone, E., Gilmore, A. K., Lehavot, K., Fargo, J., Suo, Y., … & Gundlapalli, A. V. (2018). Gender
ABSTRACT: Severe mental illness (SMI) and substance use disorders (SUD) are among the more chronic and costly mental health conditions treated in the Department of Veterans Affairs (VA). Service use patterns of returning veterans with SMI and SUD have received little attention. We examined gender differences in the utilization of VA services among a national sample of Operations Enduring Freedom, Iraqi Freedom, and New Dawn (OEF/OIF/OND) VA patients with SMI, SUD, and their comorbidity (SMI/SUD) in their first year of established VA care (N=24,166).
Raskind, M. A., Peskind, E. R., Chow, B., Harris, C., Davis-Karim, A., Holmes, H., … & Rosenheck, R. A. (2018). Trial of
ABSTRACT: In randomized trials, prazosin, an α1-adrenoreceptor antagonist, has been effective in alleviating nightmares associated with post-traumatic stress disorder (PTSD) in military veterans.
Roggenkamp, H., & Li, G. (2018). Tai Chi as a potential intervention for symptoms of mild Traumatic Brain Injury in Veterans.
ABSTRACT: Many Veterans of the conflicts in Afghanistan/Iraq who experienced repeated concussions due to blast exposure, also referred to as mild traumatic brain injury (mTBI), have persistent post-concussive symptoms (PCS). Additionally, these Veterans often have comorbid, overlapping posttraumatic stress disorder (PTSD) symptoms that further impact recovery. Emerging evidence supports the effectiveness of Tai Chi in improving physical and mental well-being, including many common PCS.
Simpson, T. L., Saxon, A. J., Stappenbeck, C., Malte, C., Lyons, R., Tell, D., … & Raskind, M. A. (2018). Double-blind
ABSTRACT: Current medications for alcohol use disorder do not target brain noradrenergic pathways. Theoretical and preclinical evidence suggests that noradrenergic circuits may be involved in alcohol reinforcement and relapse. After a positive pilot study, the authors tested the α-1 adrenergic receptor antagonist prazosin to treat alcohol use disorder in a larger sample.
Tinajero, R., Williams, P., Cribbet, M., Rau, H., Bride, D., & Suchy, Y. (2018). Nonrestorative sleep in healthy,
ABSTRACT: Previous research suggests that nonrestorative sleep (NRS), even in the absence of insomnia symptoms or other sleep disorders, may be associated with daytime dysfunction. This study examined the association between NRS and daytime dysfunction in healthy adults screened for insomnia and sleep apnea.
Tucker, R., Testa, R., Simpson, T. L., Shipherd, J., Blosnich, J., & Lehavot, K. (2018). Hormone therapy, gender
ABSTRACT: Access to transition-related medical interventions (TRMIs) for transgender veterans has been the subject of substantial public interest and debate. To better inform these important conversations, the current study investigated whether undergoing hormone or surgical transition intervention(s) relates to the frequency of recent suicidal ideation (SI) and symptoms of depression in transgender veterans.
Undurti, A., Colasurdo, E., Sikkema, C., Schultz, J., Peskind, E. R., Pagulayan, K. F., & Wilkinson, C. (2018). Chronic
ABSTRACT: The most frequent injury sustained by US service members deployed to Iraq or Afghanistan is mild traumatic brain injuries (mTBI), or concussion, by far most often caused by blast waves from improvised explosive devices or other explosive ordnance. TBI from all causes gives rise to chronic neuroendocrine disorders with an estimated prevalence of 25-50%. The current study expands upon our earlier finding that chronic pituitary gland dysfunction occurs with a similarly high frequency after blast-related concussions.
Wang, L., Raskind, M. A., Wilkinson, C., Shofer, J., Sikkema, C., Szot, P., … & Peskind, E. R. (2018). Associations
ABSTRACT: This study evaluated the effects of Alzheimer disease (AD) on the relationship between the brain noradrenergic system and hypothalamic pituitary adrenocortical axis (HPA). Specifically, relationships between cerebrospinal fluid (CSF) norepinephrine (NE) and CSF cortisol were examined in cognitively normal participants and participants with AD dementia and amnestic mild cognitive impairment (aMCI). We hypothesized that there would a positive association between these 2 measures in cognitively normal controls and that this association would be altered in AD.
Wyse, J. J., Gordon, A. J., Dobscha, S. K., Morasco, B. J., Tiffany, E., Drexler, K., ... Lovejoy, T. I. (2018). Medications
ABSTRACT: The US Department of Veterans Affairs (VA), the largest health care system in the US, has been confronted with the health care consequences of opioid disorder (OUD). Increasing access to quality OUD treatment, including pharmacotherapy, is a priority for the VA. We examine the history of medications (e.g., methadone, buprenorphine, injectable naltrexone) used in the treatment of OUD within VA, document early and ongoing efforts to increase access and build capacity, primarily through the use of buprenorphine, and summarize research examining barriers and facilitators to prescribing and medication receipt. (Link to full article not available)
Yarborough, B. J. H., Stumbo, S. P., Stoneburner, A., Smith, N., Dobscha, S. K., Deyo, R. A., Morasco, B. J. (2018).
ABSTRACT: Objective: to examine the correlates and odds of receiving overlapping benzodiazepine and opioid prescriptions and whether co-prescription was associated with greater odds of falling or visiting the emergency department. Read full research article: Correlates of benzodiazepine use and adverse outcomes among patients with chronic pain prescribed long-term opioid therapy
Zou, Y., Murray, D., Durazzo, T., Schmidt, T. P., Murray, T. A., & Meyerhoff, D. J. (2018). White matter microstructural
ABSTRACT: Identification of neural correlates of relapse to alcohol after treatment is clinically important as it may inform better substance abuse treatment. Few studies have specifically analyzed the white matter microstructure in treatment seekers as it might relate to relapse risk versus long-term abstinence. Using 4 Tesla diffusion tensor imaging, we compared two groups of one-month-abstinent treatment-seekers, who were classified based on their drinking status between six and nine months after treatment initiation.
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