Attention A T users. To access the menus on this page please perform the following steps. 1. Please switch auto forms mode to off. 2. Hit enter to expand a main menu option (Health, Benefits, etc). 3. To enter and activate the submenu links, hit the down arrow. You will now be able to tab or arrow up or down through the submenu options to access/activate the submenu links.

MIRECC / CoE

Menu
Menu

Quick Links

Veterans Crisis Line Badge
My healthevet badge
EBenefits Badge
 

VISN 1 New England MIRECC Current Human Neurobiological Research

Return to Research Page

Genome-wide Association Studies of Alcohol, Opioid, and Nicotine Dependence
Contact: Joel Gelernter, M.D. (Joel.Gelernter@va.gov)

Gene discovery can lead to risk prediction and identification of new biological targets for drug therapies. Genome-wide association studies may be used to identify genes influencing risk for the disorders under study without any prior knowledge of their physiology. Thus, they are well suited to discover novel mechanisms. We have had multiple projects funded to permit us to study a set of substance dependence traits in both European-American and African-American individuals. We hope that this work will lead to gene discovery which can lead to risk prediction and identification of new biological targets for drug therapies.
Publications: (1) Han, S., Yang, B-Z., Kranzler, H.R., Oslin, D., Anton, R., & Gelernter. J. (2011). Association of CHRNA4 polymorphisms with smoking behavior in two populations. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 156(4), 421-429; (2) Herman, A.I., Jatlow, P.I., Gelernter, J., Listman, J.B., & Sofuoglu, M. (2013). COMT Val158MET modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers. Pharmacogenomics, 13(6), 490-497; (3) Li, D., Zhao, H., & Gelernter, J. (2011). Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases. Biological Psychiatry, 70(6), 504-512; (4) Li, D., Zhao, H., & Gelernter, J. (2012). Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseases. Human Genetics, 131(8), 1361-1374; (5) Xie, P., Kranzler, H.R., Farrer, L., & Gelernter, J. (2012). Serotonin transporter 5-HTTLPR genotype moderates the effects of childhood adversity on post-traumatic stress disorder risk: A replication study. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 159B(6), 644-652; (6) Xie, P., Kranzler, H.R., Krauthammer, M., Cosgrove, K.P., Oslin, D., Anton, R.F., Farrer, L.A., Picciotto, M.R., Krystal, J.H., Zhao, H., & Gelernter, J. (2011). Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence. Biological Psychiatry, 70(6), 528-536; (7) Xie, P., Kranzler, H.R., Zhang, H., Oslin, D., Anton, R.F., Farrer, L.A., & Gelernter, J. (2012). Childhood adversity increases risk for nicotine dependence and interacts with alpha-5 nicotinic acetylcholine receptor genotype specifically in males. Neuropsychopharmacology, 37, 669-676; (8) Herman, A.I., Jatlow, P.I., Gelernter, J., Listman, J.B., & Sofuoglu, M. (2013). COMT Val158MET modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers. Pharmacogenomics, 13(6), 490-497; (9) Arias, A.J., Gelernter, J., Gueorguieva, R., Ralevski, E., & Petrakis, I. (2014). Pharmacogenetics of naltrexone and disulfiram in alcohol dependent, dually diagnosed Veterans. The American Journal on Addictions, 23(3), 288-293; and (10) Jensen, K.P., Herman, A.I., Morean, M.E., Kranzler, H.R., Gelernter, J., & Sofuoglu, M. (2014). FKBP5 variation is associated with the acute and chronic effects of nicotine. Pharmacogenomics Journal, 15(4), 340-346.

Return to Top

Contact

Mehmet Sofuoglu, M.D., Ph.D.
Director
203-937-4809
Mehmet.Sofuoglu@va.gov

Patricia Sweeney, Psy.D., CPRP
Director for Education
781-687-3015
Patricia.Sweeney@va.gov

Richard Carson, LCSW
Administrative Officer
203-932-5711 Ext. 4338
Richard.Carson@va.gov

Ilan Harpaz-Rotem, Ph.D.
Co-Director for MIRECC Fellowship Program
203-932-5711 Ext. 2599
Ilan.Harpaz-Rotem@va.gov

Suzanne Decker, Ph.D.
Co-Director for MIRECC Fellowship Program
203-932-5711 Ext. 7425
Suzanne.Decker@va.gov