MIRECC / CoE
PTSD, TBI and Other Research Activities at the NW MIRECC
PTSD, TBI and Other Research Activities at the NW MIRECCThe VISN 20 Northwest Mental Illness Research, Education and Clinical Center improves the health and well-being of Veterans by developing, evaluating, and disseminating novel effective treatments for military posttraumatic stress disorder (PTSD) and its complex comorbidities or co-occurring diagnoses. The most prominent of these co-occurring difficulties faced by Veterans are traumatic brain injury (mTBI), alcohol use disorder (AUD), chronic pain (in particular, post-concussive headaches), cognitive impairment, while others face an increased risk for neurodegenerative disorders (chronic traumatic encephalopathy [CTE] and Alzheimer's disease [AD]).
The Northwest Mental Illness Research, Education and Clinical Center approaches research in two ways: clinical and translational. In many instances, NW MIRECC partners with Veteran and non-Veteran volunteers as clinical research subjects to develop and evaluate effective treatments for military PTSD and its associated conditions, including mild traumatic brain injury (mTBI), substance use disorders, chronic pain, and dementia. (See current research and call for volunteers.)
Clinical ResearchThrough careful design and implementation of clinical research studies and with the help of volunteers in a wide range of research protocols, the Northwest Mental Illness Research, Education and Clinical Center conducts cutting-edge measurements of brain structure to analyze their implication on behavior, --and engages volunteers in in-depth analysis of psychological, social and environmental factors that contribute to the maintenance of posttraumatic stress disorder and symptoms of mild traumatic brain injury. NW MIRECC investigators are leaders in the performance of research lumbar punctures and in the innovative use of a common blood pressure medication (i.e., prazosin (link prazosin to 4/8/19 write-up)) for trauma-related nightmares, anxiety, and other behavioral symptoms that affect many Veterans with PTSD.
Translational ResearchAnother route to identifying potential treatments for PTSD and its associated conditions (specify associated conditions) is through laboratory studies that do not require the enrollment of Veterans. The nationally acclaimed NW MIRECC translational neuroscience program is a multidisciplinary research program dedicated to understanding and treating these disorders. through basic discovery science and the development of innovative treatment strategies. Together, teams of clinicians and scientists work side-by-side to characterize and model the key features of these clinical problems, including the co-existing conditions of TBI and neurodegenerative disorders, and to then translate our findings from scientific theory or animal models into practical applications for Veterans.
NW MIRECC investigators collaborate with researchers and clinicians across the University of Washington, University of Utah, Uniformed Services University of Health Sciences, Oregon Health and Science University, Department of Defense, and Veterans Affairs, as well as a host of academic, government, and industry partners around the world.
Call for Research Volunteers:The Northwest Mental Illness Research, Education and Clinical Center is looking for volunteers who have not served in the military and for Veterans who served at a variety of times and who have experienced a variety of service-related conditions, including posttraumatic stress disorder (PTSD), mild traumatic brain injury (mTBI), posttraumatic headaches, neurodegeneration and dementia, and Gulf War Veterans’ illness. Go to current research and see volunteer opportunities.