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PRIME Care Study

The purpose of this study is to determine the effectiveness of providing depressed Veterans and their providers the results of pharmacogenetic (PGx) testing for psychotropic medications. The study focuses on whether and how patients and providers use genetic test results given to them at the time an antidepressant is to be initiated to treat Major Depressive Disorder (MDD) and whether use of the test results improves patient outcomes. MDD is one of the most common conditions associated with military service and combat exposure, increases suicide risk, and worsens the course of common medical conditions, making it a leading cause of disability and mortality. Validation of a PGx test to personalize the treatment of MDD represents an important opportunity to improve the health care of Veterans. Veteran recruitment will take place at 19 different VA Sites

Introduction to Pharmacogenetics: PRIME Care Study:
This whiteboard video briefly explains pharmacogenetics, what it is, and how it is being used in health care today. The role of pharmacogenetics in the VA PRIME Care study is described. Running time: 2:59
Intended Audience: Patients and Providers

PRIME Care Study Introduction:
This video summarizes the VA PRIME Care study, including public health significance, study design, the pharmacogenetic test used, study hypotheses, and future directions.  
Running time: 21:59
Intended Audience: Providers

Introduction to Pharmacogenetic Testing for Providers:
This video provides an introduction to pharmacogenetics and discusses the potential application of pharmacogenetics to the mental health field. An overview of the VA PRIME Care study is presented.
Running time: 5:42
Intended Audience: Providers

Using Your Patient Test Results:
Utilizing four case examples, this video walks through the application of pharmacogenetic test results used in the VA PRIME Care Study.
Running time: 14:47
Intended Audience: Providers

Talking to Your Patients About Test Results:
Through the use of vignettes, this video provides guidance to providers on how to talk to their patients about the pharmacogenetic test used in the VA PRIME Care study and approaches for reviewing the results.
Running time: 15:01
Intended Audience: Providers

VA PRIME Care Playlist:

To find out which VA Medical Centers are participating in this study and the local contact information for each, click here. ID: NCT03170362



David W. Oslin, M.D.
Principal Investigator
CPL Michael J Crescenz VA Medical Center

Erin Ingram
Senior Research Coordinator
CPL Michael J Crescenz VA Medical Center
215-823-5800 Ext. 2895