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PRIME Care Study

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PRIME Care Dissemination to Date

(updated 2/5/2024)

Peer-Reviewed Journal Articles


Longitudinal Influence of Prescribed Antidepressants on Fecal and Oral Microbiomes among Veterans with Major Depressive Disorder [link]
Journal of Neuropsychiatry and Clinical Neurosciences
Andrew J. Hoisington, Ph.D.; Kelly A. Stearns-Yoder, M.A.; Christopher E. Stamper, Ph.D.; Joseph A. Simonetti, M.D., MPH; David W. Oslin, M.D.; Lisa A. Brenner, Ph.D.

Providers' Use of Pharmacogenetic Testing to Inform Antidepressant Prescribing: Results of Qualitative Interviews [link]
Psychiatric Services  |  August 2023
Bonnie M. Vest, PhD; Laura O. Wray, PhD; Michael E. Thase, MD; Laura A. Brady, PhD; Sara R. Chapman MS, OTR/L; David W. Oslin, MD

Baseline Platelet Serotonin in a Multi-site Treatment Study of Depression in Veterans Administration Patients: Distributions and Effects of Demographic Variables and Serotonin Reuptake
 Inhibitors [link]
Journal of Affective Disorders  |  February 2023
George M. Anderson, PhD; Christine M. Ramsey, PhD; Kevin G. Lynch, PhD; Joel Gelernter, MD; David W. Oslin, MD

Drug-Drug-Gene Interaction Risk among Opioid Users in the US Department of Veterans Affairs [link]
Pain | December 2022
Catherine Chanfreau-Coffinier, PhD; Sony Tuteja, PharmD, PhD; Leland Hull, MD; Sally MacDonald; Olga Efimova; Jill Bates, PharmD; Deepak Voora, MD; David W. Oslin, MD; Scott L. Duvall, PhD; Julie A. Lynch, PhD, RN

***Main Outcomes***
Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission 
of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial [link]
Journal of the American Medical Association | July 2022
David W. Oslin, MD; Kevin G. Lynch, PhD; Mei-Chiung Shih, PhD; Erin P. Ingram; Laura O. Wray; Sara R. Chapman, MS, OTR/L;  Henry R. Kranzler, MD; Joel Gelernter, MD; Jeffrey M. Pyne, MD; Annjanette Stone; Scott L. DuVall; PhD; Lisa Soleymani Lehmann, MD, PhD; Michael E. Thase, MD; PRIME Care Research Group; Muhammad Aslam, MD; Steven L. Batki, MD; James M. Bjork, PhD; Frederic C. Blow, PhD; Lisa A. Brenner, PhD; Peijun Chen, MD, PhD; Shivan Desai, MD; Eric W. Dieperink, MD; Scott C. Fears, MD; Matthew A. Fuller, PharmD, BCPP, FASHP; Courtney S. Goodman, PharmD, BCPP; David P. Graham, MD; Gretchen L. Haas, PhD; Mark B. Hamner, MD; Amy W. Helstrom, PhD; Robin A. Hurley, MD; Michael S. Icardi, MD; George J. Jurjus, MD; Amy M. Kilbourne, MD, MPH; Julie A. Kreyenbuhl, PharmD, PhD; Daniel J. Lache, MD; Steven P. Lieske, MD, PhD; Julie A. Lynch, PhD, RN, MBA; Laurence J. Meyer, MD, PhD; Cristina Montalvo, MD, MBS; Sumitra Muralidhar, PhD; Michael J. Ostacher, MD, MPH; Gayla Y. Paschall, PhD; Paul N. Pfeiffer, MD; Susana Prieto, MD; Ronald M. Przygodzki, MD; Mohini Ranganathan, MBBS; Mercedes M. Rodriguez-Suarez, MD; Hannah Roggenkamp, MD; Steven A. Schichman, MD; John S. Schneeweis; Joseph A. Simonetti, MD, MPH; Stuart R. Steinhauer, PhD; Trisha Suppes, MD, PhD; Maria A. Umbert, MD; Jason L. Vassy, MD; Deepak Voora, MD; Ilse R. Wiechers, MD, MPP, MHS; Amanda E. Wood, PhD

Daily Steps and Depressive Symptoms: A Longitudinal Evaluation of Patients with Major Depressive Disorder in the Precision Medicine in Mental Health Care Study [link]
Journal of Affective Disorders | January 2022
Christine M. Ramsey, PhD; Kevin G. Lynch, PhD; Philip R. Gehrman, PhD; Srinivasan Vairavan, PhD; Vaibhav A. Narayan, PhD, MBA; Qingqin S. Li, PhD; David W. Oslin, MD

Study Design and Implementation of the PRecision Medicine In MEntal health Care (PRIME Care) Trial. [link]
Contemporary Clinical Trials | February 2021
David W. Oslin, MD; Sara R. Chapman, MS, OTR/L; Scott L. Duvall, PhD; Joel Gelernter, MD; Erin P. Ingram; Henry R. Kranzler, MD; Lisa S. Lehmann, MD; Julie A. Lynch, PhD, RN; Kevin G. Lynch, PhD; Jeffrey M. Pyne, MD; Mei-Chiung Shih, PhD; Annjanette Stone; Michael E. Thase, MD; Laura O. Wray, PhD

Prevalence of Predicted Gene-Drug Interactions for Antidepressants in the Treatment of Major Depressive Disorder in the Precision Medicine in Mental Health Care Study [link]
Journal of Affective Disorders | March 2021
Christine M. Ramsey, PhD; Kevin G. Lynch, PhD; Michael E. Thase, MD; Joel Gelernter, MD; Henry R. Kranzler, MD; Jeffrey M. Pyne, MD; Ming-Chieh Shih, MD, PhD; Annjanette Stone; David W. Oslin, MD

Primary Care and Mental Health Providers' Perceptions of Implementation of Pharmacogenetics Testing for Depression Prescribing [link]
BMC Psychiatry | October 28, 2020
Bonnie M. Vest, PhD; Laura O. Wray, PhD; Laura A. Brady, PhD; Michael E. Thase, MD; Gregory P. Beehler, PhD; Sara R. Chapman, MS, OTR/L; Leland E. Hull, MD; David W. Oslin, MD

Early Adoption of Pharmacogenetic Testing for Veterans Prescribed Psychotropic Medications [link]

Pharmacogenomics | August 8, 2019
Leland E. Hull, Catherine Chanfreau-Coffinier, PhD; Sony Tuteja, PharmD; Dan Berlowitz, MD; Lisa S. Lehmann, MDDavid W. Oslin, MD; Jeffrey M. Pyne, MD; Scott L. Duvall, PhD; Julie A. Lynch, PhD, RN

Projected Prevalance of Actionable Pharmacogenetic Variants and Level A Drugs Prescribed Among U.S. Veterans Health Administration Pharmacy Users
[link]
JAMA Network Open | June 7, 2019
Catherine Chanfreau-Coffinier, PhD; Leland E. Hull, MD; Julie A. Lynch, PhD, RN; Scott L. Duvall, PhD; Scott M. Damrauer, Franscesca E. Cunningham, PharmD; Benjamin F. Voight, PhD; Michael E. Matheny, MD; David W. Oslin, MD; Michael S. Icardi, MD; Sony Tuteja, PharmD

Gene-Based Prescribing is Here. Are Providers Ready? [link]
American Journal of Medicine | March 12, 2019
Leland E. Hull, MD; Lisa S. Lehmann, MD; Julie A. Lynch, PhD, RN

VA Primary Care and Mental Health Providers' Comfort with Genetic Testing: Survey Results from the PRIME Care Study [link]
Journal of General Internal Medicine | January 2, 2019  
Leland E. Hull, MD; Kevin G. Lynch, PhD; David W. Oslin, MD


Oral Presentations

Primary Care and Mental Health Provider Perceptions of Pharmacogenetic Testing for Depression: Qualitative Results from PRIME Care Study Focus Groups
HSR&D/QUERI 2019 National Conference (Washington, D.C.) | October 30, 2019
Laura O. Wray, PhD; Bonnie M. Vest, PhD; Laura A. Brady, PhD; Leland E. Hull, MD; Gregory P. Beehler, PhD; Sara R. Chapman, MS, OTR/L; Michael E. Thase, MD; David W. Oslin, MD


Poster Presentations

Implementation Data During a Pragmatic Clinical Trial to Inform Future Implementation Strategies: Results from PRIME Care
13th Annual Conference on the Science of Dissemination and Implementation (Virtual) | December 15-17, 2020
Bonnie M. Vest, PhD; Laura O. Wray, PhD; Gregory P. Beehler, PhD, MA; Leland E. Hull, MD, MPH; Laura A. Brady, PhD; Sara R. Chapman, MS, OTR/L; Michael E. Thase, MD

Integrating Implementation Science (IS) into an RCT: PRIME Care 
AcademyHealth Annual Conference on the Science of Dissemination and Implementation in Health (Washington, D.C.) | December 14-16, 2019
Laura O. Wray, PhD; David W. Oslin, MD; Gregory P. Beehler, PhD, MA; Bonnie M. Vest, PhD; Laura A. Brady, PhD; Leland E. Hull, MD, MPH; Michael E. Thase, MD; Sara R. Chapman, MS, OTR/L; Andrea Ford, MS

Identifying Provider Characteristics Associated with Patient Referral for Pharmacogenetic Testing: A Quantitative Analysis from the PRIME Care Study
HSR&D/QUERI 2019 National Conference (Washington, D.C.) | October 30, 2019
Christine M. Ramsey, PhD; Leland E. Hull, MD; Kevin G. Lynch, PhD; David W. Oslin, MD

Developing a Strategic Implementation Plan for Pre-emptive Pharmacogenomic Testing in the Department of Veterans Affairs
Clinical Pharmacogenetics Implementation Consortium (CPIC) Meeting (Memphis) | June 6, 2019
Julie A. Lynch, PhD; Kyung Min Lee, PhD; Leland E. Hull, MD; Catherine Chanfreau-Coffinier, PhD; Scott L. DuVall, PhD; Sony Tuteja, PharmD; David W. Oslin MD; Michael S. Icardi, MD; Michael Kelley, MD; Deepak Voora, MD

Integrating Implementation Science into a Large Pharmacogenetics Trial: The VA Precision Medicine in Mental Health Care Study
AcademyHealth Annual Research Meeting (Washington, D.C.) | June 3, 2019
Laura O. Wray, PhD; David W. Oslin, MD; Bonnie Vest, PhD; Sara Chapman, MS, OTR/L; Laura Brady, PhD

Projecting the Impact of Pharmacogenetics on Veteran Pain Management
AcademyHealth Annual Research Meeting (Washington, D.C.) | June 3, 2019
Catherine Chanfreau-Coffinier, PhD; Julie A. Lynch, PhD; Leland E. Hull, MD; David W. Oslin MD; Sony Tuteja, PharmD

Predicted Prevalance of Actionable Pharmacogenetic Variants and Associated Drug Use in the VHA Patient Population: Impact and Implications of Adopting Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Treatment of Veterans 
American Society of Human Genetics Annual Meeting (San Diego) | Oct. 15-16, 2018
Leland E. Hull, MD; Sony Tuteja, PharmD; Catherine Chanfreau-Coffinier, PhD; Olga Efimova, MD, PhD; David W. Oslin, MD; Gregorio Coronado; Scott L. DuVall, PhD; Julie A. Lynch, PhD

Utilization and Impact of a Psychiatric Pharmacogenetic Panel in the Department of Veterans Affairs
American Society of Human Genetics Annual Meeting (San Diego) | October 15-16, 2018
34th International Conference on Pharmacoepidemiology | Aug. 22-26, 2018
Leland E. Hull, MD; Sony Tuteja, PharmD; Catherine Chanfreau-Coffinier, PhD; Olga Efimova, MD, PhD; David W. Oslin, MD; Gregorio Coronado; Scott L. DuVall, PhD; Julie A. Lynch, PhD
 

ClinicalTrials.gov ID: NCT03170362