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Sierra Pacific (VISN 21) MIRECC

VA Imaging Consortium:
Improving Brain Stimulation with Imaging (IBSI)


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For the past 20 years clinicians using transcranial magnetic stimulation (TMS) have directed stimulation at brain regions guessing their locations based on landmarks on the scalp rather than using information from MRI’s. This group of six centers studies identifies the regions that are actually stimulated with this approach by collecting MRI’s in patients undergoing brain stimulation along with a marker that shows where on the scalp the stimulation was delivered. From this information it is possible to test whether patients stimulated close to a particular brain region have more benefit from therapy thus enabling clinicians to produce better outcomes. Our first study applied this approach to the largest rTMS clinical trial conducted in the VA led by the Cooperative Study Program (CSP556, PI Jerome Yesavage). We have been working with several other investigators showing them how to collect MRI’s with markers identifying treatment locations and identifying the brain regions and networks underlying those regions. Join us!

Collaborating VA Hospitals

Coordinator Center: Palo Alto
Investigator: Allyson Rosen

Sites/Site Investigators

Mark George, Bashar Badran

Palo Alto
Jerome Yesavage, Joseph Cheng

Michael Thase, Ruben Gur

Steven Forman

San Francisco VAMC
Daniel Mathalon

Deborah Yurgelun-Todd, Perry Renshaw

Others Contributing Imaging Data
Palo Alto
Maheen Adamson, Wesson Ashford