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VISN 4 MIRECC Newsflash

Summer 2023


We were delighted to learn that the main outcomes of the VA-funded Precision Medicine in Mental Health Care (PRIME Care) study were selected as part of a three-way tie for the VA Health Services Research & Development (HSR&D) Best Research Paper of the Year Award!

David Oslin, M.D.’s paper, “Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial,” was published in JAMA in July 2022.

The PRIME Care study, which enrolled 1,944 Veterans and 676 providers at 22 sites across VA, found that pharmacogenomic testing resulted in fewer prescriptions of antidepressants with adverse drug-gene interactions and higher depression remission rates.

The HSR&D award honors papers that are based on research important to Veterans’ health and care and to the VA Healthcare System. The research must be groundbreaking, highly visible, and published in a high-impact journal. Recipients receive a research-related supplement and a dissemination program through the HSR&D website and a special cyberseminar. Read the full announcement here. Learn more about the PRIME Care study here.

The results have been presented to several VHA offices, including to the Under Secretary for Health and various clinical program offices. An overview was also provided to staffers for the Senate Committee on Veterans’ Affairs. In addition, the paper received significant publicity, including coverage by VA News and VA Research Currents, and was highlighted by more than 30 news outlets, including NPR’s Science Friday podcast, the Philadelphia Inquirer, and Medscape, as well as many blogs and tweets. The article is in the top 5% of research outputs scored by Altmetric and was listed among 2022’s 10 most significant advances in genomic medicine in the American Journal of Human Genetics.

Dr. Oslin is director of the VISN 4 Mental Illness Research, Education, and Clinical Center (MIRECC), an investigator at the Center for Health Equity Research and Promotion (CHERP), Associate Chief of Staff for Behavioral Health at the Corporal Michael J. Crescenz VA Medical Center in Philadelphia, and a professor of Psychiatry at the Perelman School of Medicine at the University of Pennsylvania. He shares this recognition with his 56 coauthors from VA sites and offices and university affiliates across the nation. VISN 4 MIRECC coauthors include Kevin Lynch, Ph.D., Erin Ingram, B.A., Sara Chapman, M.S., OTR/L, Henry Kranzler, M.D., Michael Thase, M.D., Gretchen Haas, Ph.D., Amy Helstrom, Ph.D., and Stuart Steinhauer, Ph.D.

Congratulations to Dr. Oslin and his whole team on this exciting achievement and for making an important contribution to Veterans’ health and the advancement of their field!

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David W. Oslin, M.D.
Director, VISN 4 MIRECC
Cpl. Michael J. Crescenz VA Medical Center