MIRECC / CoE

2022 VISN 20 MIRECC Staff Research Articles and Presentations

VISN 20 MIRECC Staff Research Articles and Presentations

The findings of NW MIRECC research are disseminated through MIRECC Presents, lectures and presentations, and publications. Below is a list of publications and presentations by VISN 20 NW MIRECC researchers and fellowship program faculty that were published in 2022.

Adeniyi, P., Fopiano, K., Banine, F., Garcia, M., Gong, X., Keene, C., Sherman, L., Bagi, Z., & Back, S. (2022). Multispectral LEDs Eliminate Lipofuscin-Associated Autofluorescence for Immunohistochemistry and CD44 Variant Detection by in Situ Hybridization in Aging Human, non-Human Primate, and Murine Brain. ASN Neuro, 14, 175909142211231. doi:10.1177/17590914221123138

Alosco, M., Mariani, M., Adler, C., Balcer, L., Bernick, C., Au, R., Banks, S., Barr, W., Bouix, S., Cantu, R., Coleman, M., Dodick, D., Farrer, L., Geda, Y., Katz, D., Koerte, I., Kowall, N., Lin, A., Marcus, D., Marek, K., McClean, M., McKee, A., Mez, J., Palmisano, J., Peskind, E. R., Tripodis, Y., Turner, R., Wethe, J., Cummings, J., Reiman, E., Shenton, M., Stern, R., Adler, C., Alosco, M., Au, R., Balcer, L., Banks, S., Barr, W., Bernick, C., Bouix, S., Cantu, R., Chen, K., Coleman, M., Cummings, J., Dodick, D., Farrer, L., Fitzsimmons, J., Geda, Y., Goldberg, J., Helm, R., Johnson, K., Katz, D., Kirov, I., Koerte, I., Kowall, N., Lin, A., Lui, Y., Marcus, D., Marek, K., Mariani, M., Marmar, C., McClean, M., McKee, A., Mez, J., Miller, J., Palmisano, J., Pasternak, O., Peskind, E. R., Protas, H., Reiman, E., Ritter, A., Shenton, M., Stern, R., Su, Y., Tripodis, Y., Turner, R., Weller, J., & Wethe, J. (2021). Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project. Alzheimer's Research and Therapy, 13 (1), 136. doi:10.1186/s13195-021-00872-x

Alosco, M., Su, Y., Stein, T., Protas, H., Cherry, J., Adler, C., Balcer, L., Bernick, C., Pulukuri, S., Abdolmohammadi, B., Coleman, M., Palmisano, J., Tripodis, Y., Mez, J., Rabinovici, G., Marek, K., Beach, T., Johnson, K., Huber, B., Koerte, I., Lin, A., Bouix, S., Cummings, J., Shenton, M., Reiman, E., McKee, A., Stern, R., Reiman, E., Su, Y., Chen, K., Protas, H., Boker, C., Alosco, M., Au, R., Cantu, R., Farrer, L., Helm, R., Katz, D., Kowall, N., Mez, J., Mercier, G., Otis, J., Stern, R., Weller, J., Simkin, I., Andino, A., Conneely, S., Diamond, C., Fagle, T., Haller, O., Hunt, T., Gullotti, N., Mariani, M., Mayville, B., McLaughlin, K., Nanna, M., Platt, T., Pulukuri, S., Rice, F., Sestak, M., McClean, M., Tripodis, Y., Annis, D., Chaisson, C., Dixon, D., Finney, C., Gallagher, K., Hartlage, K., Lu, J., Martin, B., Ojo, E., Palmisano, J., Pine, B., Ramachandran, J., Bouix, S., Fitzsimmons, J., Lin, A., Koerte, I., Pasternak, O., Shenton, M., Arcinieago, H., Billah, T., Bonke, E., Breedlove, K., Coello, E., Coleman, M., Jung, L., Liao, H., Loy, M., Rizzoni, E., Schultz, V., Silva, A., Vessey, B., Wiegand, T., Banks, S., Bernick, C., Miller, J., Ritter, A., Sabbagh, M., de la Cruz, R., Durant, J., Golceker, M., Harmon, N., Kaylegian, K., Long, R., Nance, C., Sandoval, P., Turner, R., Marek, K., Serrano, A., Adler, C., Dodick, D., Geda, Y., Wethe, J., Falk, B., Duffy, A., Howard, M., Montague, M., Osgood, T., Babcock, D., Bellgowan, P., Balcer, L., Barr, W., Goldberg, J., Wisniewski, T., Kirov, I., Lui, Y., Marmar, C., Hasanaj, L., Serrano, L., Al-Kharafi, A., George, A., Martin, S., Riley, E., Runge, W., Cummings, J., Peskind, E. R., Colasurdo, E., Marcus, D., Gurney, J., Greenwald, R., & Johnson, K. (2022). Associations between near end-of-life flortaucipir PET and postmortem CTE-related tau neuropathology in six former American football players. European Journal of Nuclear Medicine and Molecular Imaging. Advance online publication. doi:10.1007/s00259-022-05963-x

Ameen-Ali, K., Bretzin, A., Lee, E., Folkerth, R., Hazrati, L., Iacono, D., Keene, C., Kofler, J., Kovacs, G., Nolan, A., Perl, D., Priemer, D., Smith, D., Wiebe, D., Stewart, W., Al-Sarraj, S., Cortes, E., Crary, J., Dams-O’Connor, K., Diaz-Arrastia, R., Dollé, J., Edlow, B., Fischl, B., Hinds, C., Johnson, V., Manley, G., Meaney, D., Okonkwo, D., Schneider, A., Schneider, J., Troakes, C., Trojanowski, J., van der Kouwe, A., & Yaffe, K. (2022). Detection of astrocytic tau pathology facilitates recognition of chronic traumatic encephalopathy neuropathologic change. Acta Neuropathologica Communications, 10 (1), 1-50. doi:10.1186/s40478-022-01353-4

Bagi, Z., Kroenke, C., Fopiano, K., Tian, Y., Filosa, J., Sherman, L., Larson, E., Keene, C., Degener O’Brien, K., Adeniyi, P., & Back, S. (2022). Association of cerebral microvascular dysfunction and white matter injury in Alzheimer’s disease. GeroScience. Advance online publication. doi:10.1007/s11357-022-00585-5

Bakken, T., Jorstad, N., Hu, Q., Lake, B., Tian, W., Kalmbach, B., Crow, M., Hodge, R., Krienen, F., Sorensen, S., Eggermont, J., Yao, Z., Aevermann, B., Aldridge, A., Bartlett, A., Bertagnolli, D., Casper, T., Castanon, R., Crichton, K., Daigle, T., Dalley, R., Dee, N., Dembrow, N., Diep, D., Ding, S., Dong, W., Fang, R., Fischer, S., Goldman, M., Goldy, J., Graybuck, L., Herb, B., Hou, X., Kancherla, J., Kroll, M., Lathia, K., van Lew, B., Li, Y., Liu, C., Liu, H., Lucero, J., Mahurkar, A., McMillen, D., Miller, J., Moussa, M., Nery, J., Nicovich, P., Niu, S., Orvis, J., Osteen, J., Owen, S., Palmer, C., Pham, T., Plongthongkum, N., Poirion, O., Reed, N., Rimorin, C., Rivkin, A., Romanow, W., Sedeño-Cortés, A., Siletti, K., Somasundaram, S., Sulc, J., Tieu, M., Torkelson, A., Tung, H., Wang, X., Xie, F., Yanny, A., Zhang, R., Ament, S., Behrens, M., Bravo, H., Chun, J., Dobin, A., Gillis, J., Hertzano, R., Hof, P., Höllt, T., Horwitz, G., Keene, C., Kharchenko, P., Ko, A., Lelieveldt, B., Luo, C., Mukamel, E., Pinto-Duarte, A., Preissl, S., Regev, A., Ren, B., Scheuermann, R., Smith, K., Spain, W., White, O., Koch, C., Hawrylycz, M., Tasic, B., Macosko, E., McCarroll, S., Ting, J., Zeng, H., Zhang, K., Feng, G., Ecker, J., Linnarsson, S., & Lein, E. (2021). Comparative cellular analysis of motor cortex in human, marmoset and mouse. Nature, 598 (7879), 111-119. doi:10.1038/s41586-021-03465-8

Balba, N., McBride, A., Callahan, M., Mist, S., Jones, K., Butler, M., Lim, M., & Heinricher, M. (2022). Photosensitivity Is Associated with Chronic Pain following Traumatic Brain Injury. Journal of Neurotrauma, 39 (17-18), 1183-1194. doi:10.1089/neu.2022.0019

Baskin, B., Lee, S., Skillen, E., Wong, K., Rau, H., Hendrickson, R. C., Pagulayan, K. F., Raskind, M. A., Peskind, E. R., Phillips, P., Cook, D. G., & Schindler, A. (2021). Repetitive Blast Exposure Increases Appetitive Motivation and Behavioral Inflexibility in Male Mice. Frontiers in Behavioral Neuroscience, 15, 792648. doi:10.3389/fnbeh.2021.792648

Berg, J., Sorensen, S., Ting, J., Miller, J., Chartrand, T., Buchin, A., Bakken, T., Budzillo, A., Dee, N., Ding, S., Gouwens, N., Hodge, R., Kalmbach, B., Lee, C., Lee, B., Alfiler, L., Baker, K., Barkan, E., Beller, A., Berry, K., Bertagnolli, D., Bickley, K., Bomben, J., Braun, T., Brouner, K., Casper, T., Chong, P., Crichton, K., Dalley, R., de Frates, R., Desta, T., Lee, S., D’Orazi, F., Dotson, N., Egdorf, T., Enstrom, R., Farrell, C., Feng, D., Fong, O., Furdan, S., Galakhova, A., Gamlin, C., Gary, A., Glandon, A., Goldy, J., Gorham, M., Goriounova, N., Gratiy, S., Graybuck, L., Gu, H., Hadley, K., Hansen, N., Heistek, T., Henry, A., Heyer, D., Hill, D., Hill, C., Hupp, M., Jarsky, T., Kebede, S., Keene, L., Kim, L., Kim, M., Kroll, M., Latimer, C., Levi, B., Link, K., Mallory, M., Mann, R., Marshall, D., Maxwell, M., McGraw, M., McMillen, D., Melief, E., Mertens, E., Mezei, L., Mihut, N., Mok, S., Molnar, G., Mukora, A., Ng, L., Ngo, K., Nicovich, P., Nyhus, J., Olah, G., Oldre, A., Omstead, V., Ozsvar, A., Park, D., Peng, H., Pham, T., Pom, C., Potekhina, L., Rajanbabu, R., Ransford, S., Reid, D., Rimorin, C., Ruiz, A., Sandman, D., Sulc, J., Sunkin, S., Szafer, A., Szemenyei, V., Thomsen, E., Tieu, M., Torkelson, A., Trinh, J., Tung, H., Wakeman, W., Waleboer, F., Ward, K., Wilbers, R., Williams, G., Yao, Z., Yoon, J., Anastassiou, C., Arkhipov, A., Barzo, P., Bernard, A., Cobbs, C., de Witt Hamer, P., Ellenbogen, R., Esposito, L., Ferreira, M., Gwinn, R., Hawrylycz, M., Hof, P., Idema, S., Jones, A., Keene, C., Ko, A., Murphy, G., Ng, L., Ojemann, J., Patel, A., Phillips, J., Silbergeld, D., Smith, K., Tasic, B., Yuste, R., Segev, I., de Kock, C., Mansvelder, H., Tamas, G., Zeng, H., Koch, C., & Lein, E. (2021). Human neocortical expansion involves glutamatergic neuron diversification. Nature, 598 (7879), 151-158. doi:10.1038/s41586-021-03813-8

Boase, K., Machamer, J., Temkin, N., Dikmen, S., Wilson, L., Nelson, L., Barber, J., Bodien, Y., Giacino, J., Markowitz, A., McCrea, M., Satris, G., Stein, M., Taylor, S., Manley, G., Adeoye, O., Bullock, M., Corrigan, J., Diaz-Arrastia, R., Ellenbogen, R., Feeser, V., Ferguson, A., Gardner, R., Goldman, D., Gopinath, S., Hemphill, J., Keene, C., Korley, F., Kramer, J., Kreitzer, N., Levin, H., Lindsell, C., Madden, C., Martin, A., McAllister, T., Merchant, R., Mukherjee, P., Ngwenya, L., Noel, F., Nolan, A., Okonkwo, D., Palacios, E., Perl, D., Puccio, A., Rabinowitz, M., Robertson, C., Rosand, J., Sander, A., Schnyer, D., Seabury, S., Sherer, M., Toga, A., Valadka, A., Vassar, M., MS, R., Vespa, P., Wang, K., Yue, J., Yuh, E., & Zafonte, R. (2021). Central Curation of Glasgow Outcome Scale-Extended Data: Lessons Learned from TRACK-TBI. Journal of Neurotrauma, 38 (17), 2419-2434. doi:10.1089/neu.2020.7528

Boehnlein, J., & Kinzie, J. (2021). Experiencing Mental Illness: Suffering, Hope, and Healing. Narrative Inquiry in Bioethics, 11 (2), 189-194. doi:10.1353/nib.2021.0070

Bohr, T., Hjorth, P., Holst, S., Hrabetová, S., Kiviniemi, V., Lilius, T., Lundgaard, I., Mardal, K., Martens, E., Mori, Y., Nägerl, U., Nicholson, C., Tannenbaum, A., Thomas, J., Tithof, J., Benveniste, H., Iliff, J. J., Kelley, D., & Nedergaard, M. (2022). The glymphatic system: Current understanding and modeling. iScience, 25 (9), 104987. doi:10.1016/j.isci.2022.104987

Brett, B., Gardner, R., Godbout, J., Dams-O’Connor, K., & Keene, C. (2022). Traumatic Brain Injury and Risk of Neurodegenerative Disorder. Biological Psychiatry, 91(5), 498-507. doi:10.1016/j.biopsych.2021.05.025

Burke, B., Latimer, C., Keene, C., Sonnen, J., McCormick, W., Bowen, J., McCurry, S., Larson, E., & Crane, P. (2021). Theoretical impact of the AT(N) framework on dementia using a community autopsy sample. Alzheimer's & Dementia, 17(12), 1879-1891. doi:10.1002/alz.12348

Burke, J., Gugger, J., Ding, K., Kim, J., Foreman, B., Yue, J., Puccio, A., Yuh, E., Sun, X., Rabinowitz, M., Vassar, M., Taylor, S., Winkler, E., Deng, H., McCrea, M., Stein, M., Robertson, C., Levin, H., Dikmen, S., Temkin, N., Barber, J., Giacino, J., Mukherjee, P., Wang, K., Okonkwo, D., Markowitz, A., Jain, S., Lowenstein, D., Manley, G., Diaz-Arrastia, R., Badjatia, N., Duhaime, A., Feeser, V., Gaudette, E., Gopinath, S., Keene, C., Korley, F., Madden, C., Merchant, R., Schnyer, D., & Zafonte, R. (2021). Association of Posttraumatic Epilepsy With 1-Year Outcomes After Traumatic Brain Injury. JAMA Network Open, 4 (12), e2140191. doi:10.1001/jamanetworkopen.2021.40191

Callaway, E., Dong, H., Ecker, J., Hawrylycz, M., Huang, Z., Lein, E., Ngai, J., Osten, P., Ren, B., Tolias, A., White, O., Zeng, H., Zhuang, X., Ascoli, G., Behrens, M., Chun, J., Feng, G., Gee, J., Ghosh, S., Halchenko, Y., Hertzano, R., Lim, B., Martone, M., Ng, L., Pachter, L., Ropelewski, A., Tickle, T., Yang, X., Zhang, K., Bakken, T., Berens, P., Daigle, T., Harris, J., Jorstad, N., Kalmbach, B., Kobak, D., Li, Y., Liu, H., Matho, K., Mukamel, E., Naeemi, M., Scala, F., Tan, P., Ting, J., Xie, F., Zhang, M., Zhang, Z., Zhou, J., Zingg, B., Armand, E., Yao, Z., Bertagnolli, D., Casper, T., Crichton, K., Dee, N., Diep, D., Ding, S., Dong, W., Dougherty, E., Fong, O., Goldman, M., Goldy, J., Hodge, R., Hu, L., Keene, C., Krienen, F., Kroll, M., Lake, B., Lathia, K., Linnarsson, S., Liu, C., Macosko, E., McCarroll, S., McMillen, D., Nadaf, N., Nguyen, T., Palmer, C., Pham, T., Plongthongkum, N., Reed, N., Regev, A., Rimorin, C., Romanow, W., Savoia, S., Siletti, K., Smith, K., Sulc, J., Tasic, B., Tieu, M., Torkelson, A., Tung, H., van Velthoven, C., Vanderburg, C., Yanny, A., Fang, R., Hou, X., Lucero, J., Osteen, J., Pinto-Duarte, A., Poirion, O., Preissl, S., Wang, X., Aldridge, A., Bartlett, A., Boggeman, L., O’Connor, C., Castanon, R., Chen, H., Fitzpatrick, C., Luo, C., Nery, J., Nunn, M., Rivkin, A., Tian, W., Dominguez, B., Ito-Cole, T., Jacobs, M., Jin, X., Lee, C., Lee, K., Miyazaki, P., Pang, Y., Rashid, M., Smith, J., Vu, M., Williams, E., Biancalani, T., Booeshaghi, A., Crow, M., Dudoit, S., Fischer, S., Gillis, J., Hu, Q., Kharchenko, P., Niu, S., Ntranos, V., Purdom, E., Risso, D., de Bézieux, H., Somasundaram, S., Street, K., Svensson, V., Vaishnav, E., Van den Berge, K., Welch, J., An, X., Bateup, H., Bowman, I., Chance, R., Foster, N., Galbavy, W., Gong, H., Gou, L., Hatfield, J., Hintiryan, H., Hirokawa, K., Kim, G., Kramer, D., Li, A., Li, X., Luo, Q., Muñoz-Castañeda, R., Stafford, D., Feng, Z., Jia, X., Jiang, S., Jiang, T., Kuang, X., Larsen, R., Lesnar, P., Li, Y., Li, Y., Liu, L., Peng, H., Qu, L., Ren, M., Ruan, Z., Shen, E., Song, Y., Wakeman, W., Wang, P., Wang, Y., Wang, Y., Yin, L., Yuan, J., Zhao, S., Zhao, X., Narasimhan, A., Palaniswamy, R., Banerjee, S., Ding, L., Huilgol, D., Huo, B., Kuo, H., Laturnus, S., Li, X., Mitra, P., Mizrachi, J., Wang, Q., Xie, P., Xiong, F., Yu, Y., Eichhorn, S., Berg, J., Bernabucci, M., Bernaerts, Y., Cadwell, C., Castro, J., Dalley, R., Hartmanis, L., Horwitz, G., Jiang, X., Ko, A., Miranda, E., Mulherkar, S., Nicovich, P., Owen, S., Sandberg, R., Sorensen, S., Tan, Z., Allen, S., Hockemeyer, D., Lee, A., Veldman, M., Adkins, R., Ament, S., Bravo, H., Carter, R., Chatterjee, A., Colantuoni, C., Crabtree, J., Creasy, H., Felix, V., Giglio, M., Herb, B., Kancherla, J., Mahurkar, A., McCracken, C., Nickel, L., Olley, D., Orvis, J., Schor, M., Hood, G., Dichter, B., Grauer, M., Helba, B., Bandrowski, A., Barkas, N., Carlin, B., D’Orazi, F., Degatano, K., Gillespie, T., Khajouei, F., Konwar, K., Thompson, C., Kelly, K., Mok, S., & Sunkin, S. (2021). A multimodal cell census and atlas of the mammalian primary motor cortex. Nature, 598 (7879), 86-102. doi:10.1038/s41586-021-03950-0

Campagnola, L., Seeman, S., Chartrand, T., Kim, L., Hoggarth, A., Gamlin, C., Ito, S., Trinh, J., Davoudian, P., Radaelli, C., Kim, M., Hage, T., Braun, T., Alfiler, L., Andrade, J., Bohn, P., Dalley, R., Henry, A., Kebede, S., Alice, M., Sandman, D., Williams, G., Larsen, R., Teeter, C., Daigle, T., Berry, K., Dotson, N., Enstrom, R., Gorham, M., Hupp, M., Dingman Lee, S., Ngo, K., Nicovich, P., Potekhina, L., Ransford, S., Gary, A., Goldy, J., McMillen, D., Pham, T., Tieu, M., Siverts, L., Walker, M., Farrell, C., Schroedter, M., Slaughterbeck, C., Cobb, C., Ellenbogen, R., Gwinn, R., Keene, C., Ko, A., Ojemann, J., Silbergeld, D., Carey, D., Casper, T., Crichton, K., Clark, M., Dee, N., Ellingwood, L., Gloe, J., Kroll, M., Sulc, J., Tung, H., Wadhwani, K., Brouner, K., Egdorf, T., Maxwell, M., McGraw, M., Pom, C., Ruiz, A., Bomben, J., Feng, D., Hejazinia, N., Shi, S., Szafer, A., Wakeman, W., Phillips, J., Bernard, A., Esposito, L., D’Orazi, F., Sunkin, S., Smith, K., Tasic, B., Arkhipov, A., Sorensen, S., Lein, E., Koch, C., Murphy, G., Zeng, H., & Jarsky, T. (2022). Local connectivity and synaptic dynamics in mouse and human neocortex. Science, 375, 6585. doi:10.1126/science.abj5861

Cheng, Z., Lozier, C. C., Lewis, M., O’Neil, M., Luoma, J. B., & Morasco, B. (2021). Investigating the role of psychological inflexibility, mindfulness, and self -compassion in PTSD. Journal of Contextual Behavioral Science, 22, 102-107.

Clouston, S., Hall, C., Kritikos, M., Bennett, D., DeKosky, S., Edwards, J., Finch, C., Kreisl, W., Mielke, M., Peskind, E. R., Raskind, M. A., Richards, M., Sloan, R., Spiro, A., Vasdev, N., Brackbill, R., Farfel, M., Horton, M., Lowe, S., Lucchini, R., Prezant, D., Reibman, J., Rosen, R., Seil, K., Zeig-Owens, R., Deri, Y., Diminich, E., Fausto, B., Gandy, S., Sano, M., Bromet, E., & Luft, B. (2022). Cognitive impairment and World Trade Centre-related exposures. Nature Reviews Neurology, 18 (2), 103-116. doi:10.1038/s41582-021-00576-8

Coffey, K. R., Lesiak, A., Marx, R., Vo, E., Garden, G., & Neumaier, J. F. (2022). A cAMP-Related Gene Network in Microglia Is Inversely Regulated by Morphine Tolerance and Withdrawal. Biological Psychiatry Global Open Science, 2(2), 180-189. doi:10.1016/j.bpsgos.2021.07.011

Coffey, K. R., Venkat, V., West, M. O., & Barker, D. J. (2021). Lateral preoptic area neurons signal cocaine self-administration behaviors. European Journal of Neuroscience, 54(7), 6397-6405.

Course, M., Gudsnuk, K., Keene, C., Bird, T., Jayadev, S., & Valdmanis, P. (2022). Aberrant splicing of PSEN2, but not PSEN1, in individuals with sporadic Alzheimer's disease. Brain. Advance online publication. doi:10.1093/brain/awac294

Damodarasamy, M., Khaing, Z., Hyde, J., Keene, C., Bentov, I., Banks, W., & Reed, M. (2022). Viable human brain microvessels for the study of aging and neurodegenerative diseases. Microvascular Research, 140, 104282. doi:10.1016/j.mvr.2021.104282

Dickstein, D., De Gasperi, R., Gama Sosa, M., Perez-Garcia, G., Short, J., Sosa, H., Perez, G., Tschiffely, A., Dams-O’Connor, K., Pullman, M., Knesaurek, K., Knutsen, A., Pham, D., Soleimani, L., Jordan, B., Gordon, W., Delman, B., Shumyatsky, G., Shahim, P., DeKosky, S., Stone, J., Peskind, E. R., Blennow, K., Zetterberg, H., Chance, S., Torso, M., Kostakoglu, L., Sano, M., Hof, P., Ahlers, S., Gandy, S., & Elder, G. (2021). Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure. Molecular Psychiatry, 26 (10), 5940-5954. doi:10.1038/s41380-020-0674-z

Djerdjaj, A., Ng, A. J., Rieger, N. S., & Christianson, J. P. (2022). The basolateral amygdala to posterior insular cortex tract is necessary for social interaction with stressed juvenile rats. Behavioural brain research, 435, 114050. doi:10.1016/j.bbr.2022

Edelman, W., Kiianitsa, K., Virmani, T., Martinez, R., Young, J., Keene, C., Bird, T., Raskind, W., & Korvatska, O. (2022). Reduced gene dosage is a common mechanism of neuropathologies caused by ATP6AP2 splicing mutations. Parkinsonism & Related Disorders, 101, 31-38. doi:10.1016/j.parkreldis.2022.06.015

Eissman, J., Dumitrescu, L., Mahoney, E., Smith, A., Mukherjee, S., Lee, M., Scollard, P., Choi, S., Bush, W., Engelman, C., Lu, Q., Fardo, D., Trittschuh, E., Mez, J., Kaczorowski, C., Hernandez Saucedo, H., Widaman, K., Buckley, R., Properzi, M., Mormino, E., Yang, H., Harrison, T., Hedden, T., Nho, K., Andrews, S., Tommet, D., Hadad, N., Sanders, R., Ruderfer, D., Gifford, K., Zhong, X., Raghavan, N., Vardarajan, B., Pericak-Vance, M., Farrer, L., Wang, L., Cruchaga, C., Schellenberg, G., Cox, N., Haines, J., Keene, C., Saykin, A., Larson, E., Sperling, R., Mayeux, R., Cuccaro, M., Bennett, D., Schneider, J., Crane, P., Jefferson, A., & Hohman, T. (2022). Sex differences in the genetic architecture of cognitive resilience to Alzheimer’s disease. Brain, 145 (7), 2541-2554. doi:10.1093/brain/awac177

Elliott, J., McBride, A., Balba, N., Thomas, S., Pattinson, C., Morasco, B., Wilkerson, A., Gill, J., & Lim, M. (2022). Feasibility and preliminary efficacy for morning bright light therapy to improve sleep and plasma biomarkers in US Veterans with TBI. A prospective, open-label, single-arm trial. PLOS ONE, 17 (4), e0262955. doi:10.1371/journal.pone.0262955

Evans, K., Barton, R., Hendrickson, R. C., & LaPlante, L. (2022). Creating Safe Spaces for Those Who Have Lived through Intimate Partner Violence. Journal of Aggression, Maltreatment & Trauma, NA, 1-16. doi:10.1080/10926771.2022.2099774

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Piantino, J., Iliff, J. J., & Lim, M. (2022). The Bidirectional Link Between Sleep Disturbances and Traumatic Brain Injury Symptoms: A Role for Glymphatic Dysfunction?. Biological Psychiatry, 91(5), 478-487. doi:10.1016/j.biopsych.2021.06.025

Prater, K., Green, K., Chiou, K., Smith, C., Sun, W., Shojaie, A., Heath, L., Rose, S., Keene, C., Logsdon, B., Snyder-Mackler, N., Blue, E., Young, J., Garden, G., & Jayadev, S. (2021). Microglia subtype transcriptomes differ between Alzheimer Disease and control human postmortem brain samples. Alzheimer's and Dementia, 17 (S2), e058474. doi:10.1002/alz.058474

Ray, L., Pike, M., Simon, M., Iliff, J. J., & Heys, J. (2021). Quantitative analysis of macroscopic solute transport in the murine brain. Fluids and Barriers of the CNS, 18 (1), 55. doi:10.1186/s12987-021-00290-z

Rieger, N. S., Guoynes, C. D., Monari, P. K., Hammond, E. R., Malone, C. L., & Marler, C. A. (2022). Neuroendocrine mechanisms of aggression in rodents. Motivation Science, 8(2), 81-105. Retrieved from https://doi.org/10.1037/mot0000260

Rieger, N. S., Varela, J. A., Ng, A. J., Granata, L., Djerdjaj, A., Brenhouse, H. C., & Christianson, J. P. (2022). Insular cortex corticotropin-releasing factor integrates stress signaling with social affective behavior. Neuropsychopharmacology, 47(6), 1156-1168. doi:10.1038/s41386-022-01292-7

Rieger, N. S., Worley, N., Ng, A., & Christianson, J. (2022). Insular cortex modulates social avoidance of sick rats. Behavioural Brain Research, 416, 113541. doi:10.1016/j.bbr.2021.113541

Salman, M., Kitchen, P., Halsey, A., Wang, M., Törnroth-Horsefield, S., Conner, A., Badaut, J., Iliff, J. J., & Bill, R. (2022). Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis. Brain, 145 (1), 64-75. doi:10.1093/brain/awab311

Schindler, A. G., Baskin, B., Juarez, B., Janet Lee, S., Hendrickson, R., Pagulayan, K., Zweifel, L. S., Raskind, M. A., Phillips, P. E. M., Peskind, E. R., & Cook, D. G. (2021). Repetitive blast mild traumatic brain injury increases ethanol sensitivity in male mice and risky drinking behavior in male combat veterans. Alcoholism, clinical and experimental research, 45(5), 1051–1064. doi:10.1111/acer.14605

Schneider, L., Bennett, D., Farlow, M., Peskind, E. R., Raskind, M. A., Sano, M., Stern, Y., Haneline, S., Welsh-Bohmer, K., O’Neil, J., Walter, R., Maresca, S., Culp, M., Alexander, R., Saunders, A., Burns, D., & Chiang, C. (2022). Adjudicating Mild Cognitive Impairment Due to Alzheimer’s Disease as a Novel Endpoint Event in the TOMMORROW Prevention Clinical Trial. The Journal of Prevention of Alzheimer's Disease, 9(4), 625-634. doi:10.14283/jpad.2022.72

Sheppard, D., Rau, H., Trittschuh, E., Werhane, M., Schindler, A., Hendrickson, R. C., Peskind, E. R., & Pagulayan, K. F. (2022). Poorer prospective memory performance is associated with reduced time monitoring among OEF/OIF/OND Veterans with a history of blast-related mild traumatic brain injury. The Clinical Neuropsychologist. doi:10.1080/13854046.2022.2068455

Sheppard, D., Rau, H., Werhane, M., Fonseca, L., Chaytor, N., Peskind, E. R., & Pagulayan, K. F. (2022). Associations between Intra-Individual Neurocognitive Variability and Prospective Memory in Veterans with Mild Traumatic Brain Injury History and Posttraumatic Stress Disorder. Archives of Clinical Neuropsychology, 37(6), 1221-1227. doi:10.1093/arclin/acac014

Simon, M., Wang, M., Ismail, O., Braun, M., Schindler, A., Reemmer, J., Wang, Z., Haveliwala, M., O’Boyle, R., Han, W., Roese, N., Grafe, M., Woltjer, R., Boison, D., & Iliff, J. J. (2022). Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid ß plaque formation in mice. Alzheimer's Research and Therapy, 14 (1), 59. doi:10.1186/s13195-022-00999-5

Somohano, V., Kaplan, J., Newman, A., O’Neil, M., & Lovejoy, T. (2022). Formal mindfulness practice predicts reductions in PTSD symptom severity following a mindfulness-based intervention for women with co-occurring PTSD and substance use disorder. Addiction Science & Clinical Practice, 17 (1), 51. doi:10.1186/s13722-022-00333-2

Somohano, V., Shank, T., Manuel, J., Mallik, D., Rehder, K., & Bowen, S. (2021). The Role of Pretreatment Expectancy on Substance Use Outcomes in Women Mandated to Mindfulness-Based Relapse Prevention. The Journal of Alternative and Complementary Medicine. doi:10.1089/acm.2021.0123

Sorg, S., Werhane, M., Merritt, V., Clark, A., Holiday, K., Hanson, K., Jak, A. J., Schiehser, D. M., & Delano-Wood, L. (2021). Research letter: PTSD symptom severity and multiple traumatic brain injuries are associated with elevated memory complaints in veterans with histories of mild TBI. Journal of Head Trauma Rehabilitation, 36 (6), 418-423. doi:10.1097/HTR.0000000000000659

Sun, D., Rakesh, G., Clarke-Rubright, E., Haswell, C., Logue, M. W., O’Leary, E., Cotton, A., Xie, H., Dennis, E., Jahanshad, N., Salminen, L., Thomopoulos, S., Rashid, F., Ching, C., Koch, S., Frijling, J., Nawijn, L., van Zuiden, M., Zhu, X., Suarez-Jimenez, B., Sierk, A., Walter, H., Manthey, A., Stevens, J., Fani, N., van Rooij, S., Stein, M., Bomyea, J., Koerte, I., Choi, K., van de Werff, S., Vermeiren, R., Herzog, J., Lebois, L., Baker, J., Ressler, K., Olson, E., Straube, T., Korgaonkar, M., Andrew, E., Zhu, Y., Li, G., Ipser, J., Hudson, A., Peverill, M., Sambrook, K., Gordon, E., Baugh, L., Forster, G., Simons, R., Simons, J., Magnotta, V., Maron-Katz, A., du Plessis, S., Disner, S., Davenport, N., Grupe, D., Nitschke, J., deRoon-Cassini, T., Fitzgerald, J., Krystal, J. H., Levy, I., Olff, M., Veltman, D., Wang, L., Neria, Y., De Bellis, M., Jovanovic, T., Daniels, J., Shenton, M., van de Wee, N., Schmahl, C., Kaufman, M., Rosso, I., Sponheim, S., Hofmann, D., Bryant, R., Fercho, K., Stein, D., Mueller, S., Phan, L., McLaughlin, K., Davidson, R., Larson, C., May, G., Nelson, S., Abdallah, C., Gomaa, H., Etkin, A., Seedat, S., Harpaz-Rotem, I., Liberzon, I., Wang, X., Thompson, P., & Morey, R. (2022). Remodeling of the cortical structural connectome in posttraumatic stress disorder: Results from the ENIGMA-PGC PTSD consortium. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. Advance online publication. doi:10.1016/j.bpsc.2022.02.008

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Torres, E., Luo, J., Boehnlein, J., Towns, D., Kinzie, J., DeBarber, A., & Raber, J. (2022). Apolipoprotein E Isoform-specific changes related to stress and trauma exposure. Translational Psychiatry, 12 (1), 125-135. doi:10.1038/s41398-022-01848-7

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Williams, R. G., Li, K., & Phillips, P. (2022). The Influence of Stress on Decision-Making: Effects of CRF and Dopamine Antagonism in the Nucleus Accumbens. Frontiers in Psychiatry, 12, 113541. doi:10.3389/fpsyt.2021.814218

Wyse, J., Mackey, K., Lovejoy, T., Kansagara, D., Tuepker, A., Gordon, A., Todd Korthuis, P., Herreid-O’Neill, A., Williams, B., & Morasco, B. (2022). Expanding access to medications for opioid use disorder through locally-initiated implementation. Addiction Science & Clinical Practice, 17 (1), 32. doi:10.1186/s13722-022-00312-7

Wyse, J., Morasco, B., Dougherty, J., Edwards, B., Kansagara, D., Gordon, A., Korthuis, P., Tuepker, A., Lindner, S., Mackey, K., Williams, B., Herreid-O’Neill, A., Paynter, R., & Lovejoy, T. (2021). Adjunct interventions to standard medical management of buprenorphine in outpatient settings: A systematic review of the evidence. Drug and Alcohol Dependence, 228, 108923. doi:10.1016/j.drugalcdep.2021.108923

VISN 20 encompasses 23% of the US land mass with medical centers in Alaska, Idaho, Oregon, and Washington. VISN 20 is home to 273 federally recognized American Indian and Alaskan Native tribes, 229 of which are located in Alaska. Serving 135 counties, VISN 20 is the largest geographic region of VA spanning three time zones, across 817,417 square miles, including Del Norte County California and Lincoln County Montana. In the fall of 1997, VISN 20 leaders from VA Puget Sound Health Care System (VAPSHCS) and the Portland VA Health Care System (VAPORHCS) were commissioned by Congress and the U.S. Department of Veterans Affairs (VA) to establish one of the first three Mental Illness Research, Education, and Clinical Centers (MIRECCs) in the United States. VAPSHCS serves Veterans from a five-state area in the Pacific Northwest with two main divisions: American Lake VA Medical Center and Seattle VA Medical Center. VA Outpatient Clinics and Vet Centers in Washington are located in Bellingham, Bellevue, Bremerton, Chehalis, Edmunds, Everett, Federal Way, Lacey, Mount Vernon, Olympia, Port Angeles, Puyallup, Richland, Renton, Silverdale, Seattle, Spokane, Union Gap, Vancouver, Walla Walla, Wenatchee, and Yakima. Veterans in Washington are also served by VA Medical Centers in Spokane, Vancouver, and Walla Walla. VAPORHCS serves Veterans in Oregon and Southwest Washington with two main divisions: Portland VA Medical Center and Vancouver VA Medical Center. VA Outpatient Clinics and Vet Centers in Oregon are located in Bend, Boardman, Brookings, Enterprise, Eugene, Fairview, Grants Pass, Hines, Hillsboro, Klamath Falls, LaGrande, Lincoln City, Newport, Portland, Salem, The Dalles, Warrenton, and West Linn. Veterans in Oregon are also served by VA Medical Centers in Roseburg, White City, and Vancouver, Washington.

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VA provides health care for Veterans from providers in the local community outside of VA. Veterans may be eligible to receive care from a community provider when VA cannot provide the care needed. VA launched its new and improved Veterans Community Care Program (VCCP) on June 6, 2019, implementing portions of the VA Maintaining Internal Systems and Strengthening Integrated Outside Networks Act of 2018 (MISSION Act), which both ended the Veterans Choice Program and established VCCP. Types of care under the new VCCP include General Community Care, Urgent Care, Emergency Care, Foreign Medical Care, Home Health and Hospice Care, Indian and Tribal Health Services, In Vitro Fertilization, State Veterans Home, and Flu Shots. Veterans work with their VA health care provider or other VA staff to see if they are eligible to receive community care based on new criteria. The VA Community Care Network (CCN) is VA’s direct link with community providers to ensure Veterans receive timely, high-quality care.

Vet Centers in the VISN 20 Health Care Network are community-based counseling centers that provide a wide range of social and psychological services, including professional readjustment counseling to eligible Veterans, active-duty Army, Navy, Marine Corps, Coast Guard, Air Force, and Space Force service members, including National Guard and Reserve components, and their families. 1-877-WAR-VETS is an around the clock confidential call center where Veterans, service members and their families can talk about their military experience or any other issue they are facing in transitioning after military service or trauma and get connected to their nearest Vet Center.

Vet Centers in VISN 20

Vet Centers provide counseling to make a successful transition from military to civilian life or after a traumatic event experienced in the military. Individual, group, marriage and family counseling is offered in addition to referral and connection to other VA or community benefits and services. If you can’t make it to a nearby Vet Center, VA offers satellite Vet Center locations and Mobile Vet Centers that may be closer to you.

Explore VA.gov

VA has a variety of mental health resources, information, treatment options, and more — all accessible to Veterans, Veterans’ supporters, and the general public. Explore the pages below to learn more about a specific mental health topic. Each of these pages includes resources, information on treatment options, and more.

Stories of Support